Aberrant pro-atrial natriuretic peptide/corin/natriuretic peptide receptor signaling is present in maternal vascular endothelium in preeclampsia
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چکیده
منابع مشابه
Evaluation of Serum Levels of N-terminal Pro Brain Natriuretic Peptide and Atrial Natriuretic Peptide in Neonates with Respiratory Distress
Background: Acute respiratory distress (ARD) is a critical respiratory failure due to lung injury of neonates leading to the clinical appearance of poor lung compliance. The aimed of the study was to evaluate the diagnostic values in differentiating respiratory from heart diseases with using of N-terminal pro brain natriuretic peptide (NT-pro BNP) and Atrial natriuretic peptide(ANP) in neonates...
متن کاملevaluation of serum levels of n-terminal pro brain natriuretic peptide and atrial natriuretic peptide in neonates with respiratory distress
background: acute respiratory distress (ard) is a critical respiratory failure due to lung injury of neonates leading to the clinical appearance of poor lung compliance. the aimed of the study was to evaluate the diagnostic values in differentiating respiratory from heart diseases with using of n-terminal pro brain natriuretic peptide (nt-pro bnp) and atrial natriuretic peptide(anp) in neonates...
متن کاملAtrial natriuretic peptide-initiated cGMP pathways regulate vasodilator-stimulated phosphoprotein phosphorylation and angiogenesis in vascular endothelium.
Nitric oxide (NO)- and atrial natriuretic peptide (ANP)-initiated cGMP signaling cascades are important in the maintenance of cardiovascular homeostasis. The molecular signaling mechanisms downstream of cGMP are not well understood, however. We have used small interfering RNA (siRNA) approaches to specifically knock down a series of signaling proteins in bovine aortic endothelial cells, and we ...
متن کاملC2238 atrial natriuretic peptide molecular variant is associated with endothelial damage and dysfunction through natriuretic peptide receptor C signaling.
RATIONALE C2238 atrial natriuretic peptide (ANP) minor allele (substitution of thymidine with cytosine in position 2238) associates with increased risk of cardiovascular events. OBJECTIVE We investigated the mechanisms underlying the vascular effects of C2238-αANP. METHODS AND RESULTS In vitro, human umbilical vein endothelial cell were exposed to either wild-type (T2238)- or mutant (C2238)...
متن کاملThe C2238 Atrial Natriuretic Peptide Molecular Variant is Associated with Endothelial Damage and Dysfunction Through Natriuretic Peptide Receptor C Signaling
IRCCS Neuromed, Pozzilli, Italy; William Harvey Heart Centre, Barts & The London School of Medicine & Dentistry, London, UK; Cardiovascular Center OLV Hospital, Aalst, Belgium; Dept. of Clinical and Molecular Medicine, School of Medicine and Psychology, University Sapienza of Rome, Ospedale S. Andrea, Rome, Italy; Dept. of Pharmacological and Biomolecular Sciences, University of Milan; and Dept...
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ژورنال
عنوان ژورنال: Pregnancy Hypertension
سال: 2018
ISSN: 2210-7789
DOI: 10.1016/j.preghy.2017.12.001